Macromolecular phasing using diffraction from multiple crystal forms
نویسندگان
چکیده
منابع مشابه
Multi-crystal anomalous diffraction for low-resolution macromolecular phasing.
Multiwavelength anomalous diffraction (MAD) and single-wavelength anomalous diffraction (SAD) are the two most commonly used methods for de novo determination of macromolecular structures. Both methods rely on the accurate extraction of anomalous signals; however, because of factors such as poor intrinsic order, radiation damage, inadequate anomalous scatterers, poor diffraction quality and oth...
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© 2006 American Institute of Physics, S-0031-9228-0603-030-4 M molecular biophysics is built on the twin pillars of genetic engineering and macromolecular structure determination. And x-ray crystallography is foremost among the methods used to determine the atomic-scale structure of macromolecules—very large molecules with sizes typically ranging from 50 to 1000 Å. X-ray crystallography played ...
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The space-group symmetry of a crystal structure imposes a point-group symmetry on its diffraction pattern, giving rise to so-called symmetry-equivalent reflections. Instances in macromolecular crystallography are discussed in which the symmetry in reciprocal space is broken, i.e. where symmetry-related reflections are no longer equivalent. Such a situation occurs when the sample suffers from si...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations and Advances
سال: 2021
ISSN: 2053-2733
DOI: 10.1107/s2053273320013650